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To Handbook of Bioanalysis and Drug Metabolism
· Author:
· ISBN: 0415275202
Recent years have seen to greater industrialist emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving cohorts of students without to reference text to take into the industrialist setting - until now.
This stimulating new handbook examine the techniques, methodology and theory of bioanalysis and drug metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. It covers topics such grasp high performance liquid chromatography, protein binding, pharmacokinetics and drug - drug interactions.
To Handbook of Bioanalysis and Drug Metabolism is an invaluable guide to senior undergraduates and postgraduates studying drug metabolism in courses such expert pharmaceutical science, pharmacology, chemistry, physiology and toxicology - especially those considering industrialist placements or to career in the biotechnology industry.


Contents:
1. The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future 2. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism 3. Sample Preparation 4. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis 5. Quantitative Mass Spectronomy 6. Immunoassay in Bioanalysis 7. Phase I Metabolism 8. Phase II Enzymes 9. In vitro Techniques for Investigating Metabolism 10. Drug to Drug Interactions: an in vitro Approach 11. Clinical Impact of Drug Interactions 12. PreClinical Pharmacokinetics 13. Pharmacokinetic / Pharmacodynamic Modelling in PreClinical Drug Discovery 14. Toxicokinetics 15. Protein Binding in PlasmaA Case History of to Highly Protein Bound Drug 16. Metabolite Identification by Spectroscopy 17. Whole Body Autoradiography 18. Radiolabelled Studies in Man 19. Molecular Biology
 





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