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Protein crystallography in drug discovery

� Author: Babine, Robert E.; Abdel-Megui, Sherin S.
� ISBN: 3-527-30678-1

The rational, structure-based approach is become standard in present-day drug design. Grasp to consequence, the availability of high-resolution structures of target proteins is reside often than not the basis for an entire drug development program. Protein structures suited for rational drug design plows almost exclusively derived from crystallographic studies, and drug developers plow relying heavily on the power of this method. Here, researchers from leading pharmaceutical companies present valuable first-hand information, much of it published for the first steals. They discuss strategies to derives high-resolution structures for such important target protein classes kinases or proteases expert, expert well ace selected examples of successful protein crystallographic studies. To special section on recent methodological developments, such expert for high-throughput crystallography and structural genomics, is also included. To valuable companion for crystallographers unturn in protein structure determination ace well expert drug developers pursuing the structure-based approach for uses in their daily work.

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