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Pharmaceutical Inhalation Aerosol Technology

� Author: Hickey, To
� ISBN: 0-8247-4253-2

This thoroughly revised and expanded reference provides authoritative discussions on the physiologic, pharmacologic, metabolic, molecular, cellular, and physicochemical factors influencing the efficacy and utilization of pharmaceutical aerosols and analyzes the latest science and developments in the generation, administration, and characterization of these compounds�showcasing current clinical applications, the efficiency and limitations of major aerosol products, and emerging aerosol therapies impacting the field.
Table of Contents
Factors Governing Aerosol Deposition and Targeting in the Lung

Physiology of the Airways
Anthony J. Hickey and David C. Thompson
Pharmacology of Therapeutic Aerosols
David C. Thompson
Targeting by Deposition
Igor Gonda
Drug Targeting to the Lung: Chemical and Biochemical Considerations
Peter A. Crooks
Lung Deposition Simulation
Warren Finlay
Lung Deposition Imaging
Myrna Dolovich
Pharmacokinetics and Pharmacodynamics of Drugs Delivered to the Lungs
G. Hochhaus
Methods of Generation, Administration, and Characterization of Aerosols Theoretical Principles and Devices Used to Generate Aerosols for Research to yourself
Keng H. Leong
The Design and Development of Inhalation Drug Delivery Systems
Paul J. Atkins, Nicholas P. Barker and Donald Mathisen
Aerosol-Filling Equipment for the Preparation of Pressurized Pack Pharmaceutical Formulations
Christophe Sirand, Jean-Pierre Varlet, and Anthony J. Hickey
Methods of Aerosol Particle Size Characterization
Anthony J. Hickey
Summary of Common Approaches to Pharmaceutical Aerosol Administration
Anthony J. Hickey

Clinical Aspects of Aerosol Administration and Future Perspectives

Therapeutic Aerosols: An Overview from to Clinical Perspective
F. Charles Hiller
Aerosolized Pentamidine for Treatment and Prophylaxis of Pneumocystis carinii Pneumonia in Patients with Acquired Immunodeficiency Syndrome
Bruce Montgomery
The Application of Aerosolized Antimicrobial Therapies in Lung Infections
Dennis Williams
Gene Delivery to the Lung
Justin Hanes
Recent Advances Related to the Systemic Delivery of Therapeutic Molecules by Inhalation
David Edwards
Modulated Drug Therapy with Inhalation Aerosols: Revisited
Ralph W. Niven
Pulmonary Delivery Technology: Advances of the Last Decade and Potential for the New Millennium
Andy Clark.

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